Regulation of DNA Pairing in Homologous Recombination
نویسندگان
چکیده
منابع مشابه
Regulation of DNA strand exchange in homologous recombination.
Homologous recombination, the exchange of DNA strands between homologous DNA molecules, is involved in repair of many structural diverse DNA lesions. This versatility stems from multiple ways in which homologous DNA strands can be rearranged. At the core of homologous recombination are recombinase proteins such as RecA and RAD51 that mediate homology recognition and DNA strand exchange through ...
متن کاملMediators of homologous DNA pairing.
Homologous DNA pairing and strand exchange are at the core of homologous recombination. These reactions are promoted by a DNA-strand-exchange protein assembled into a nucleoprotein filament comprising the DNA-pairing protein, ATP, and single-stranded DNA. The catalytic activity of this molecular machine depends on control of its dynamic instability by accessory factors. Here we discuss proteins...
متن کاملFunctions of homologous DNA recombination
Homologous DNA (or genetic) recombination plays important roles in heredity and evolution. A recent study has shown that a physical linkage established by recombination between two or more homologous DNA regions or molecules is essential for the precise disjunction of homologous chromosomes in meiosis and the recovery of collapsed DNA replication forks. These physical linkages in recombination ...
متن کاملRecombination-dependent mtDNA partitioning: in vivo role of Mhr1p to promote pairing of homologous DNA.
Yeast mhr1-1 was isolated as a defective mutation in mitochondrial DNA (mtDNA) recombination. About half of mhr1-1 cells lose mtDNA during growth at a higher temperature. Here, we show that mhr1-1 exhibits a defect in the partitioning of nascent mtDNA into buds and is a base-substitution mutation in MHR1 encoding a mitochondrial matrix protein. We found that the Mhr1 protein (Mhr1p) has activit...
متن کاملHomologous recombination and its regulation
Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for chromosomal pairing and exchange during meiosis. However, some forms of HR can also lead to undesirable DNA rearrangements. Multiple regulatory mechanisms have evolved to ensure that HR takes place at the right time, place and manner. Several of these impinge on the control of Rad51 nucleofilaments that ...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2014
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a017954